The Optiscan FIVE 1 fluorescent in vivo endo-microscope can be applied to a broad range of preclinical applications.
This innovative instrument provides unique sub-micron resolution microscopic imaging information, without physically removing tissue for histological processing and examination.
This makes possible the direct observation of life’s molecular mechanisms without the need to sacrifice animals or remove tissues from the body. Observing gene therapies in action, watching drug therapies find their molecular targets and tracking stem cells as they migrate through tissue can all be achieved with this form of imaging.
This creates new vistas in research and drug development, as well as a window to future medical imaging paradigms.
Gene therapy and cell tracking: In this example, “gene gun” technology is used to administer genetic material into the skin of living mice. The cells in the skin express the gene and make a green fluorescent protein (GFP), which is directly observed using Optiscan miniature confocal microscope technology.
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Molecular targeted imaging: A fluorescently tagged antibody specific to cancer antigens is administered to a mouse with a tiny tumour in the skin. The antibody is directly observed localising on the surface of the cancer cells using Optiscan miniature confocal microscope technology.
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Dynamic imaging of blood flow: Optiscan miniature confocal microscope technology is used to directly observe the streaming of blood cells through the tiniest blood vessels, the capillaries in the liver.
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Vascular response monitoring: Blood flow through the liver is observed in real time in response to administration of vasoactive drugs.
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