Publications

2021

• “A phase I study of a PARP1-targeted topical fluorophore for the detection of oral cancer.” European Journal of Nuclear Medicine and Molecular Imaging.

  Demétrio de Souza França, P., S. Kossatz, C. Brand, D. Karassawa Zanoni, S. Roberts, N. Guru, D. Adilbay, A. Mauguen, C. Valero Mayor, W. A. Weber, H. Schöder, R. A. Ghossein, I. Ganly, S. G. Patel and T. Reiner

• Fluorescence In Vivo Endomicroscopy: High-Resolution, 3-Dimensional Confocal Laser Endomicroscopy (Part 1). Microscopy Today, 29(2), 32-37.

  Rangrez, M., Bussau, L., Ifrit, K., & Delaney, P. (2021).

• Molecular Imaging of Glucose Metabolism for Intraoperative Fluorescence Guidance During Glioma Surgery. Molecular Imaging and Biology.

  Belykh, E., Jubran, J. H., George, L. L., Bardonova, L., Healey, D. R., Georges, J. F., Quarles, C. C., Eschbacher, J. M., Mehta, S., Scheck, A. C., Nakaji, P., Preul, M. C.

• Intraoperative imaging of brain tumors with fluorescein: confocal laser endomicroscopy in neurosurgery. Clinical and user experience. Neurosurgical Focus FOC, 50(1), E19.

  Julius, H., Karl-Michael, S., Saida, Z., Martin, P., Markus, J. R., & Nils Ole, S.

2020

• Poly(ADP-ribose)polymerase1: A potential molecular marker to identify cancer during colposcopy procedures. J Nucl Med. doi:10.2967/jnumed.120.253575

  Demetrio de Souza Franca, P., Guru, N., Kostolansky, A. R., Mauguen, A., Pirovano, G., Kossatz, S., Roberts, S., Abrahao, M., Patel, S. G., Reiner, T., Jewell, E.

• Ex Vivo Fluorescein-Assisted Confocal Laser Endomicroscopy (CONVIVO® System) in Patients With Glioblastoma: Results From a Prospective Study. Frontiers in Oncology 10(2911).

  Acerbi, F., B. Pollo, C. De Laurentis, F. Restelli, J. Falco, I. G. Vetrano, M. Broggi, M. Schiariti, I. Tramacere, P. Ferroli and F. DiMeco (2020).

• Fluorescence-guided resection of tumors in mouse models of oral cancer. Scientific Reports, 10(1), 11175. doi:10.1038/s41598-020-67958-8

  Demétrio de Souza França, P., Guru, N., Roberts, S., Kossatz, S., Mason, C., Abrahão, M., Ghossein, R. A., Patel, S. G., & Reiner, T.

• Spp24 is associated with endocytic signalling, lipid metabolism, and discrimination of tissue integrity for ‘leaky-gut’ in inflammatory bowel disease. Scientific Reports, 10(1), 12932.

  Wasinger, V. C., Lu, K., Yau, Y. Y., Nash, J., Lee, J., Chang, J., Chang, J., Paramsothy, S., Kaakoush, N. O., Mitchell, H. M., Leong, R. W. L.

• Intraoperative Confocal Laser Endomicroscopy Ex Vivo Examination of Tissue Microstructure During Fluorescence-Guided Brain Tumor Surgery. Frontiers in Oncology, 10(2584).

  Belykh, E., X. Zhao, B. Ngo, D. S. Farhadi, V. A. Byvaltsev, J. M. Eschbacher, P. Nakaji and M. C. Preul (2020).

• Validation of the use of a fluorescent PARP1 inhibitor for the detection of oral, oropharyngeal and oesophageal epithelial cancers. Nature Biomedical Engineering. 2020;4(3):272-85. doi: 10.1038/s41551-020-0526-9.

  Kossatz S, Pirovano G, Demétrio De Souza França P, Strome AL, Sunny SP, Zanoni DK, Mauguen A, Carney B, Brand C, Shah V, Ramanajinappa RD, Hedne N, Birur P, Sihag S, Ghossein RA, Gönen M, Strome M, Suresh A, Molena D, Ganly I, Kuriakose MA, Patel SG, Reiner T.

2019

• Fluorescein- and EGFR-Antibody Conjugated Silica Nanoparticles for Enhancement of Real-time Tumor Border Definition Using Confocal Laser Endomicroscopy in Squamous Cell Carcinoma of the Head and Neck. Nanomaterials, 9(10).

  Watermann, A., Gieringer, R., Bauer, A.-M., Kurch, S., Kiesslich, R., Tremel, W., Gosepath, J., Brieger, J.

• Fluorescence Image Histology Pattern Transformation Using Image Style Transfer. Frontiers in Oncology, 9(519). doi:10.3389/fonc.2019.00519

  Izadyyazdanabadi, M., Belykh, E., Zhao, X., Moreira, L. B., Gandhi, S., Cavallo, C., . . . Yang, Y.

• Progress in Confocal Laser Endomicroscopy for Neurosurgery and Technical Nuances for Brain Tumor Imaging With Fluorescein. Frontiers in Oncology, 9(554). doi:10.3389/fonc.2019.00554

  Belykh, E., Miller, E. J., Carotenuto, A., Patel, A. A., Cavallo, C., Martirosyan, N. L., . . . Preul, M. C.

• Many Patients With Irritable Bowel Syndrome Have Atypical Food Allergies Not Associated With Immunoglobulin E. Gastroenterology, 157(1), 109-118.e105. doi:10.1053/j.gastro.2019.03.046

  Fritscher-Ravens, A., Pflaum, T., Mösinger, M., Ruchay, Z., Röcken, C., Milla, P. J., Das, M., Böttner, M., Wedel, T., & Schuppan, D.

• PARP1 as a biomarker for early detection and intraoperative tumor delineation in epithelial cancers – first-in-human results. bioRxiv, 663385. doi:10.1101/663385

  Kossatz, S., Pirovano, G., De Souza França, P. D., Strome, A. L., Sunny, S. P., Zanoni, D. K., . . . Reiner, T.

• Fluorescence-based tracing of transplanted intestinal epithelial cells using confocal laser endomicroscopy. Stem Cell Research & Therapy, 10(1), 148. Retrieved from https://doi.org/10.1186/s13287-019-1246-5. doi:10.1186/s13287-019-1246-5

  Bergenheim, F., Seidelin, J. B., Pedersen, M. T., Mead, B. E., Jensen, K. B., Karp, J. M., & Nielsen, O. H.

• Using Confocal Endomicroscopy for Digital Biopsy During Brain Surgery: Presentation of a Study Protocol. Studies in health technology and informatics, 258, 237-238.

  Fotteler, M., Holl, F., Käsbach, C., Schlegel, J., & Swoboda, W.

2018

• METABOLIC AND BLOOD-BRAIN BARRIER MARKERS FOR FLUORESCENCE-GUIDED SURGERY: SYSTEMATIC HIGH-RESOLUTION MICROSCOPY INVESTIGATION IN HUMAN RELEVANT EXPERIMENTAL GLIOMAS. Neuro-Oncology, 20(suppl_6), vi270-vi270. doi:10.1093/neuonc/noy148.1123

  Belykh, E., Carotenuto, A., George, L., Miller, E., Healey, D. R., Luna-Melendez, E., Byvaltsev, V. A., Staren, M., Scheck, A., Quarles, C., Mehta, S., Nakaji, P., & Preul, M.

• Acetylsalicylic acid-tris-hydroxymethyl-aminomethane reduces colon mucosal damage without causing gastric side effects in a rat model of colitis. Inflammopharmacology, 26(1), 261-271. doi:10.1007/s10787-017-0354-z

  Varga, G., Ugocsai, M., Hartmann, P., Lajkó, N., Molnár, R., Szűcs, S., Jász, D. K., Érces, D., Ghyczy, M., Tóth, G., & Boros, M. J. I

• Probe-based three-dimensional confocal laser endomicroscopy of brain tumors: technical note. Cancer Management and Research, Volume 10, 3109-3123. doi:10.2147/cmar.S165980

  Belykh, E., Patel, A. A., Miller, E. J., Bozkurt, B., Yağmurlu, K., Woolf, E. C., Scheck, A. C., Eschbacher, J. M., Nakaji, P., & Preul, M. C

• Real-time in vivo Microscopic Imaging of Equine Endometrium Using Confocal Laser Endomicroscopy: Preliminary Observations and Feasibility Study. Journal of Equine Veterinary Science, 66. doi:10.1016/j.jevs.2018.05.153

  Gallacher, K., Woolford, L., Santos, L. C., & Kind, K. L

• Confocal endomicroscopy during brain surgery. laser+photonics.

  Leierseder, S

• Prospects for Theranostics in Neurosurgical Imaging: Empowering Confocal Laser Endomicroscopy Diagnostics via Deep Learning. Front Oncol, 8, 240. doi:10.3389/fonc.2018.00240

  Izadyyazdanabadi, M., Belykh, E., Mooney, M. A., Eschbacher, J. M., Nakaji, P., Yang, Y., & Preul, M. C

• Real-time in vivo optical biopsy using confocal laser endomicroscopy to evaluate distal margin in situ and determine surgical procedure in low rectal cancer. Surgical Endoscopy. doi:10.1007/s00464-018-6519-z

  Liu, Z., Luo, X., Jiang, W., Chen, D., Chen, W., Li, K., Liu, X., Cui, Z., Li, Z., Han, Z., Liu, S., Li, G., Xu, C., & Yan, J.

• The utilization of intraoperative confocal laser endomicroscopy during the fluorescence guided surgery for brain tumors. Neuro-Oncology, 20(suppl_6), vi139-vi139. doi:10.1093/neuonc/noy148.582

  Belykh, E., Cavallo, C., Zhao, X., Miller, E., Patel, A. A., Martirosyan, N. L., Byvaltsev, V. A., Spetzler, R. F., Eschbacher, J., Nakaji, P., & Preul, M.

• Improving utility of brain tumor confocal laser endomicroscopy: objective value assessment and diagnostic frame detection with convolutional neural networks. Progress in Biomedical Optics and Imaging – Proceedings of SPIE.

  Izadyyazdanabadi, M.

• Convolutional neural networks: Ensemble modeling, fine-tuning and unsupervised semantic localization for neurosurgical CLE images. Journal of Visual Communication and Image Representation, 54, 10-20. doi:10.1016/j.jvcir.2018.04.004

  Izadyyazdanabadi, M., Belykh, E., Mooney, M., Martirosyan, N., Eschbacher, J., Nakaji, P., Preul, M. C., & Yang, Y.

2017

• Inhalation of methane preserves the epithelial barrier during ischemia and reperfusion in the rat small intestine. Surgery, 161(6), 1696-1709. doi:https://doi.org/10.1016/j.surg.2016.12.040

  Mészáros, A. T., Büki, T., Fazekas, B., Tuboly, E., Horváth, K., Poles, M. Z., Szűcs, S., Varga, G., Kaszaki, J., & Boros, M

• Early assessment of tumor response to photodynamic therapy using combined diffuse optical and diffuse correlation spectroscopy to predict treatment outcome. Oncotarget, 8(12), 19902-19913. doi:10.18632/oncotarget.15720

  Thong, P., Lee, K., Toh, H.-J., Dong, J., Tee, C.-S., Low, K.-P., Chang, P.-H., Bhuvaneswari, R., Tan, N.-C., & Soo, K.-C

• The potential role of optical biopsy in the study and diagnosis of environmental enteric dysfunction. Nature Reviews Gastroenterology &Amp; Hepatology, 14, 727. Retrieved from http://dx.doi.org/10.1038/nrgastro.2017.147. doi:10.1038/nrgastro.2017.147

  Thompson, A. J., Hughes, M., Anastasova, S., Conklin, L. S., Thomas, T., Leggett, C., . . . Yang, G.-Z.

• Evaluation of immunological markers of ovine vaginal irritation: Implications for preclinical assessment of non-vaccine HIV preventive agents. Journal of Reproductive Immunology, 124, 38-43. doi: https://doi.org/10.1016/j.jri.2017.09.014

  Milligan, G. N., Vargas, G., Vincent, K. L., Zhu, Y., Bourne, N., & Motamedi, M.

2016

• Reduced mucosal side-effects of acetylsalicylic acid after conjugation with tris-hydroxymethyl-aminomethane. Synthesis and biological evaluation of a new anti-inflammatory compound. European Journal of Pharmacology, 781, 181-189. doi:https://doi.org/10.1016/j.ejphar.2016.04.019

  Varga, G., Lajkó, N., Ugocsai, M., Érces, D., Horváth, G., Tóth, G., Boros, M., & Ghyczy, M

• C5a inhibitor protects against ischemia/reperfusion injury in rat small intestine. Microbiology and Immunology, 60(1), 35-46. doi:doi:10.1111/1348-0421.12338

  Tuboly, E., Futakuchi, M., Varga, G., Érces, D., Tőkés, T., Mészáros, A., Kaszaki, J., Suzui, M., Imai, M., Okada, A., Okada, N., Boros, M., & Okada, H

• Handheld confocal laser endomicroscopic imaging utilizing tumor-specific fluorescent labeling to identify experimental glioma cells in vivo. Surgical Neurology International, 7(Suppl 40), S995-S1003. doi:10.4103/2152-7806.195577

  Martirosyan, N. L., Georges, J., Kalani, M. Y. S., Nakaji, P., Spetzler, R. F., Feuerstein, B. G., & Preul, M. C.

• Complement C5a inhibition improves late hemodynamic and inflammatory changes in a rat model of nonocclusive mesenteric ischemia. Surgery, 159(3), 960-971. doi:10.1016/j.surg.2015.10.020

  Érces, D., Nógrády, M., Varga, G., Szűcs, S., Mészáros, A. T., Fischer-Szatmári, T., Cao, C., Okada, N., Okada, H., Boros, M., & Kaszaki, J

• Comparison of in vivo confocal endomicroscopy with other diagnostic modalities to detect intracellular helicobacters. The Veterinary Journal, 213, 78-83. doi:https://doi.org/10.1016/j.tvjl.2016.03.014

  Sharman, M., Bacci, B., Simpson, K., & Mansfield, C

• In Vivo Rectal Mucosal Barrier Function Imaging in a Large-Animal Model by Using Confocal Endomicroscopy: Implications for Injury Assessment and Use in HIV Prevention Studies. Antimicrobial Agents and Chemotherapy, 60(8), 4600

  Vargas, G., Vincent, K. L., Zhu, Y., Szafron, D., Brown, T. C., Villarreal, P. P., Bourne, N., Milligan, G. N., & Motamedi, M

• Pathomechanism and therapeutic possibilities of mitochondrial dysfunction in ischemia-reperfusion. (PhD), University of Szeged, Retrieved from http://doktori.bibl.u-szeged.hu/3216/

  Strifler, G.

• Intraoperative Fluorescence Imaging for Personalized Brain Tumor Resection: Current State and Future Directions. Front Surg, 3, 55. doi:10.3389/fsurg.2016.00055

  Belykh, E., Martirosyan, N. L., Yagmurlu, K., Miller, E. J., Eschbacher, J. M., Izadyyazdanabadi, M., Bardonova, L. A., Byvaltsev, V. A., Nakaji, P., & Preul, M. C

• Computer Aided Diagnosis for Confocal Laser Endomicroscopy in Advanced Colorectal Adenocarcinoma. PLoS One, 11(5), e0154863. doi:10.1371/journal.pone.0154863

  Stefanescu, D., Streba, C., Cartana, E. T., Saftoiu, A., Gruionu, G., & Gruionu, L. G

• Advanced endoscopic imaging: European Society of Gastrointestinal Endoscopy (ESGE) Technology Review. Endoscopy, 48(11), 1029-1045. doi:10.1055/s-0042-118087

  Goetz, M

• A pilot study of confocal laser endomicroscopy for diagnosing gastrointestinal mucosa-associated lymphoid tissue (MALT) lymphoma. Surgical Endoscopy and Other Interventional Techniques, 30(7), 2879-2885. doi:10.1007/s00464-015-4572-4

  Dolak, W., Kiesewetter, B., Müllauer, L., Mayerhoefer, M., Troch, M., Trauner, M., Häfner, M., Raderer, M., & Püspök, A. J. S. E.

• The learning curve, interobserver, and intraobserver agreement of endoscopic confocal laser endomicroscopy in the assessment of mucosal barrier defects. Gastrointest Endosc, 83(4), 785-791 e781. doi:10.1016/j.gie.2015.08.045

  Chang, J., Ip, M., Yang, M., Wong, B., Power, T., Lin, L., Xuan, W., Phan, T. G., & Leong, R. W

• Prospective evaluation of the utility of intraoperative confocal laser endomicroscopy in patients with brain neoplasms using fluorescein sodium: experience with 74 cases. Neurosurg Focus, 40(3), E11. doi:10.3171/2016.1.FOCUS15559

  Martirosyan, N. L., Eschbacher, J. M., Kalani, M. Y., Turner, J. D., Belykh, E., Spetzler, R. F., Nakaji, P., & Preul, M. C.

• Light and sound – emerging imaging techniques for inflammatory bowel disease. World Journal of Gastroenterology, 22(25), 5642-5654.

  Knieling, F., & Waldner, M. J.

2015

• Protein kinase C delta null mice exhibit structural alterations in articular surface, intra-articular and subchondral compartments. Arthritis Research and Therapy, 17(1), 210. doi:10.1186/s13075-015-0720-4

  Yang, X., Teguh, D., Wu, J.-P., He, B., Kirk, T. B., Qin, S., Li, S., Chen, H., Xue, W., Ng, B., Chim, S. M., Tickner, J., Xu, J. J. A. R

• Preparation, in vitro and in vivo evaluation of mPEG-PLGA nanoparticles co-loaded with syringopicroside and hydroxytyrosol. Journal of Materials Science: Materials in Medicine, 27(2), 24. doi:10.1007/s10856-015-5641-x

  Guan, Q., Sun, S., Li, X., Lv, S., Xu, T., Sun, J., Feng, W., Zhang, L., & Li, Y

• The development of confocal arthroscopy as optical histology for rotator cuff tendinopathy. Journal of Microscopy, 259(3), 269-275. doi:doi:10.1111/jmi.12260

  Wu, J. P., Walton, M., Wang, A., Anderson, P., Wang, T., Kirk, T. B., & Zheng, M. H

• Characterization of lesions in the stomach: will confocal laser endomicroscopy replace the pathologist? Best Pract Res Clin Gastroenterol, 29(4), 589-599. doi:10.1016/j.bpg.2015.05.013

  Goetz, M

2014

• Potential application of a handheld confocal endomicroscope imaging system using a variety of fluorophores in experimental gliomas and normal brain. Neurosurgical Focus, 36(2), E16. doi:10.3171/2013.11.Focus13486

  Martirosyan N. L. , Georges J. , Eschbacher J. M. , Cavalcanti D. D. , Elhadi A. M. , Abdelwahab M. G. , Scheck A. C. , Nakaji P , Spetzler R. F. , & Preul M. C

• In vivo visualization of GL261-luc2 mouse glioma cells by use of Alexa Fluor–labeled TRP-2 antibodies. Neurosurgical Focus, 36(2), E12. doi:10.3171/2013.12.Focus13488

  Kathryn E. Fenton, Nikolay L. Martirosyan, Mohammed G. Abdelwahab, Stephen W. Coons, Mark C. Preul, & Adrienne C. Scheck

• In Vivo Histologically Equivalent Evaluation of Gastric Mucosal Topologic Morphology in Dogs By using Confocal Endomicroscopy. Journal of Veterinary Internal Medicine, 28(3), 799-808. doi:doi:10.1111/jvim.12332

  Sharman, M. J., Bacci, B., Whittem, T., & Mansfield, C. S

• Beyond standard image-enhanced endoscopy confocal endomicroscopy. Gastrointest Endosc Clin N Am, 24(3), 427-434. doi:10.1016/j.giec.2014.03.012

  Teubner, D., Kiesslich, R., Matsumoto, T., Rey, J. W., & Hoffman, A

• In vivo endomicroscopy improves detection of Barrett’s esophagus–related neoplasia: a multicenter international randomized controlled trial (with video). Gastrointestinal Endoscopy, 79(2), 211-221.

  Canto, M. I., Anandasabapathy, S., Brugge, W., Falk, G. W., Dunbar, K. B., Zhang, Z., Woods, K., Almario, J. A., Schell, U., Goldblum, J., Maitra, A., Montgomery, E., & Kiesslich, R

• Molecular confocal laser endomicroscopy: a novel technique for in vivo cellular characterization of gastrointestinal lesions. World Journal of Gastroenterology, 20(24), 7794-7800.

  Karstensen, J. G., Klausen, P. H., Saftoiu, A., & Vilmann, P.

2013

• Miniaturized Handheld Confocal Microscopy Identifies Focal Brain Invasion in a Mouse Model of Aggressive Meningioma. Brain Pathology, 23(4), 371-377. doi:doi:10.1111/bpa.12039

  Peyre, M., Clermont-Taranchon, E., Stemmer-Rachamimov, A., & Kalamarides, M

2012

• Toward real-time virtual biopsy of oral lesions using confocal laser endomicroscopy interfaced with embedded computing. J Biomed Opt, 17(5), 056009. doi:10.1117/1.JBO.17.5.056009

  Thong, P. S., Tandjung, S. S., Movania, M. M., Chiew, W. M., Olivo, M., Bhuvaneswari, R., Seah, H. S., Lin, F., Qian, K., & Soo, K. C

• Confocal Laser Endomicroscopy for Diagnosis and Histomorphologic Imaging of Brain Tumors In Vivo. PLoS One, 7(7), e41760. doi:10.1371/journal.pone.0041760

  Foersch, S., Heimann, A., Ayyad, A., Spoden, G. A., Florin, L., Mpoukouvalas, K., Kiesslich, R., Kempski, O., Goetz, M., & Charalampaki, P

• A new method in the diagnosis of reflux esophagitis: confocal laser endomicroscopy. Gastrointest Endosc, 75(4), 864-869. doi:10.1016/j.gie.2011.11.013

  Venkatesh, K., Cohen, M., Abou-Taleb, A., Thomas, S., Taylor, C., & Thomson, M

• The learning curve, accuracy, and interobserver agreement of endoscope-based confocal laser endomicroscopy for the differentiation of colorectal lesions. Gastrointest Endosc, 75(6), 1211-1217.

  Kuiper, T., Kiesslich, R., Ponsioen, C., Fockens, P., & Dekker, E.

• Local barrier dysfunction identified by confocal laser endomicroscopy predicts relapse in inflammatory bowel disease. Gut, 61(8), 1146

  Kiesslich, R., Duckworth, C. A., Moussata, D., Gloeckner, A., Lim, L. G., Goetz, M., Pritchard, D. M., Galle, P. R., Neurath, M. F., & Watson, A. J. M

2011

• In vivo real-time imaging of the liver with confocal endomicroscopy permits visualization of the temporospatial patterns of hepatocyte apoptosis. American Journal of Physiology – Gastrointestinal and Liver Physiology, 301(5), G764-G772. doi:10.1152/ajpgi.00175.2011

  Goetz, M., Ansems, J. V., Galle, P. R., Schuchmann, M., & Kiesslich, R

• Experienced versus inexperienced confocal endoscopists in the diagnosis of gastric adenocarcinoma and intestinal metaplasia on confocal images. Gastrointest Endosc, 73(6), 1141-1147. doi:10.1016/j.gie.2011.01.068

  Lim, L. G., Yeoh, K. G., Salto-Tellez, M., Khor, C. J., Teh, M., Chan, Y. H., So, J. B., Rajnakova, A., Shen, E., Srivastava, S., & Ho, K. Y

• Intraoperative confocal microscopy for brain tumors: a feasibility analysis in humans. Neurosurgery, 68(2 Suppl Operative), 282-290; discussion 290. doi:10.1227/NEU.0b013e318212464e

  Sanai, N., Eschbacher, J., Hattendorf, G., Coons, S. W., Preul, M. C., Smith, K. A., Nakaji, P., & Spetzler, R. F.

• Confocal laser endomicroscopy is a new imaging modality for recognition of intramucosal bacteria in inflammatory bowel disease in vivo. Gut, 60(1), 26-33. doi:10.1136/gut.2010.213264

  Moussata, D., Goetz, M., Gloeckner, A., Kerner, M., Campbell, B., Hoffman, A., Biesterfeld, S., Flourie, B., Saurin, J.-C., Galle, P. R., Neurath, M. F., Watson, A. J. M., & Kiesslich, R.

2010

• Miniaturized Handheld Confocal Microscopy for Neurosurgery: Results in an Experimental Glioblastoma Model. Neurosurgery, 66(2). doi:10.1227/01.NEU.0000365772.66324.6F

  Sankar, T. M. D., Peter M. PhD; Ryan, Robert W. MD; Eschbacher, Jennifer MD; Abdelwahab, Mohammed BS; Nakaji, Peter MD; Coons, Stephen W. MD; Scheck, Adrienne C. PhD; Smith, Kris A. MD; Spetzler, Robert F. MD; Preul, Mark C. MD

• In vivo molecular imaging of colorectal cancer with confocal endomicroscopy by targeting epidermal growth factor receptor. Gastroenterology, 138(2), 435-446. doi:10.1053/j.gastro.2009.10.032

  Goetz, M., Ziebart, A., Foersch, S., Vieth, M., Waldner, M. J., Delaney, P., Galle, P. R., Neurath, M. F., & Kiesslich, R

• In Vivo Molecular Imaging of Somatostatin Receptors in Pancreatic Islet Cells and Neuroendocrine Tumors by Miniaturized Confocal Laser-Scanning Fluorescence Microscopy. Endocrinology, 151(5), 2179-2188. doi:10.1210/en.2009-1313

  Fottner, C., Mettler, E., Goetz, M., Schirrmacher, E., Anlauf, M., Strand, D., Schirrmacher, R., Klöppel, G., Delaney, P., Schreckenberger, M., Galle, P. R., Neurath, M. F., Kiesslich, R., & Weber, M. M

• Advances of endomicroscopy for gastrointestinal physiology and diseases. American Journal of Physiology – Gastrointestinal and Liver Physiology, 298(6), G797-G806. doi:10.1152/ajpgi.00027.2010

  Goetz, M., & Kiesslich, R

• In Vivo Diagnosis and Classification of Colorectal Neoplasia by Chromoendoscopy-Guided Confocal Laser Endomicroscopy. Clinical Gastroenterology and Hepatology, 8(4), 371-378. doi:10.1016/j.cgh.2009.08.006

  Sanduleanu, S., Driessen, A., Gomez-Garcia, E., Hameeteman, W., de Bruïne, A., & Masclee, A

• Characterization and identification of gastric hyperplastic polyps and adenomas by confocal laser endomicroscopy. Surgical Endoscopy, 24(3), 517-524. doi:10.1007/s00464-009-0608-y

  Li, W.-B., Zuo, X.-L., Zuo, F., Gu, X.-M., Yu, T., Zhao, Y.-A., Zhang, T.-G., Zhang, J.-P., & Li, Y.-Q

• Classification of inflammation activity in ulcerative colitis by confocal laser endomicroscopy. American Journal of Gastroenterology, 105(6), 1391-1396. doi:10.1038/ajg.2009.664

  Li, C. Q., Xie, X. J., Yu, T., Gu, X. M., Zuo, X. L., Zhou, C. J., Huang, W. Q., Chen, H., & Li, Y. Q

• Confocal endomicroscopy: a novel application for imaging of oral and oropharyngeal mucosa in human. European Archives of Oto-Rhino-Laryngology, 267(3), 443-448. doi:10.1007/s00405-009-1035-3

  Haxel, B. R., Goetz, M., Kiesslich, R., & Gosepath, J.

• Near-infrared confocal imaging during mini-laparoscopy: a novel rigid endomicroscope with increased imaging plane depth. J Hepatol. 2010;53(1):84-90.

  Goetz M, Deris I, Vieth M, Murr E, Hoffman A, Delaney P, et al.

• A Pilot Study of the Feasibility of Confocal Endomicroscopy for Examination of the Human Airway. Journal of Bronchology & Interventional Pulmonology, 17(2), 126-130.

  Musani, A. I. M., Sims, M. M., Sareli, C. M., Russell, W. R., McLaren, W. J. P., Delaney, P. M. B. H., . . . Panettieri, R. A. J. M.

• In vivo intravital endoscopic confocal fluorescence microscopy of normal and acutely injured rat lungs. Laboratory Investigation, 90(6), 824-834. doi:10.1038/labinvest.2010.76

  Chagnon, F., Fournier, C., Charette, P. G., Moleski, L., Payet, M. D., Dobbs, L. G., & Lesur, O.

2009

• Simultaneous confocal laser endomicroscopy and chromoendoscopy with topical cresyl violet. Gastrointestinal Endoscopy, 70(5), 959-968. doi:https://doi.org/10.1016/j.gie.2009.04.016

  Goetz, M., Toermer, T., Vieth, M., Dunbar, K., Hoffman, A., Galle, P. R., Neurath, M. F., Delaney, P., & Kiesslich, R

• Imaging of goblet cells as a marker for intestinal metaplasia of the stomach by one-photon and two-photon fluorescence endomicroscopy

  Bao, H., Boussioutas, A., Reynolds, J., Russell, S., & Gu, M

• Detection of cervical intraepithelial neoplasia in vivo using confocal endomicroscopy. BJOG: An International Journal of Obstetrics and Gynaecology, 116(12), 1663-1670. doi:10.1111/j.1471-0528.2009.02261

  Tan, J., Quinn, M. A., Pyman, J. M., Delaney, P. M., & McLaren, W. J

• Mechanisms of Epithelial Cell Shedding in the Mammalian Intestine and Maintenance of Barrier Function. Annals of the New York Academy of Sciences, 1165(1), 135-142. doi:doi:10.1111/j.1749-6632.2009.04027

  Watson, A. J. M., Duckworth, C. A., Guan, Y., & Montrose, M. H

• Confocal laser endomicroscopy diagnosis of gastric adenocarcinoma in a patient treated for gastric diffuse large-B-cell lymphoma. Digestive and Liver Disease, 41(6), 447-449. doi:10.1016/j.dld.2007.11.019

  Trovato, C., Sonzogni, A., Ravizza, D., Pruneri, G., Rossi, M., de Roberto, G., Tamayo, D., Vanazzi, A., Fiori, G., & Crosta, C

• Confocal laser endomicroscopy for the detection of mucosal changes in ileal pouch after restorative proctocolectomy. Digestive and Liver Disease, 41(8), 578-585. doi:10.1016/j.dld.2008.09.019

  Trovato, C., Sonzogni, A., Fiori, G., Ravizza, D., Tamayo, D., Botti, F., Carrara, A., Zefelippo, A., Contessini-Avesani, E., & Crosta, C

• Inflammatory cloacogenic polyp: diagnostic features by confocal endomicroscopy. Gastrointestinal Endoscopy, 69(3), 595-598. doi:10.1016/j.gie.2008.04.013

  Sanduleanu, S., Driessen, A., Hameeteman, W., van Gemert, W., de Bruïne, A., & Masclee, A

• Real time intraoperative confocal laser microscopy-guided surgery. Annals of Surgery, 249(5), 735-737. doi:10.1097/SLA.0b013e3181a38f11

  Nguyen, N. Q., Biankin, A. V., Leong, R. W. L., Chang, D. K., Cosman, P. H., Delaney, P., Kench, J. G., & Merrett, N. D

• Optical EMR: confocal endomicroscopy-targeted EMR of focal high-grade dysplasia in Barrett’s esophagus. Gastrointestinal Endoscopy, 69(1), 170-172. doi:10.1016/j.gie.2008.03.1068

  Leung, K. K., Maru, D., Abraham, S., Hofstetter, W. L., Mehran, R., & Anandasabapathy, S

• Editorial: Taking optical biopsies with confocal endomicroscopy. Journal of Gastroenterology and Hepatology (Australia), 24(11), 1701-1703. doi:10.1111/j.1440-1746.2009.06011

  Leong, R. W., Chang, D., Merrett, N. D., & Biankin, A. V

• Confocal laser endomicroscopy in Barrett’s esophagus and endoscopically inapparent Barrett’s neoplasia: a prospective, randomized, double-blind, controlled, crossover trial. Gastrointest Endosc, 70(4), 645-654. doi:10.1016/j.gie.2009.02.009

  Dunbar, K. B., Okolo, P., 3rd, Montgomery, E., & Canto, M. I

• Confocal chromolaser endomicroscopy: a supplemental diagnostic tool prior to transanal endoscopic microsurgery of rectal tumors? International Journal of Colorectal Disease, 25(1), 71. doi:10.1007/s00384-009-0813-0

  Borschitz, T., & Kiesslich, R. J. I. J. o. C. D

• Malignant transformation in inflammatory bowel disease: Prevention, surveillance and treatment – New techniques in endoscopy. Digestive Diseases, 27(4), 571-575. doi:10.1159/000233300

  Bojarski, C

2008

• Confocal endomicroscopy in patients with ulcerative colitis. 23(s2), S286-S290. doi:doi:10.1111/j.1440-1746.2008.05559.x

  Watanabe, O., Ando, T., Maeda, O., Hasegawa, M., Ishikawa, D., Ishiguro, K., Ohmiya, N., Niwa, Y., & Goto, H.

• In vivo confocal laser laparoscopy allows real time subsurface microscopy in animal models of liver disease. J Hepatol, 48(1), 91-97. doi:10.1016/j.jhep.2007.07.029

  Goetz, M., Vieth, M., Kanzler, S., Galle, P. R., Delaney, P., Neurath, M. F., & Kiesslich, R

• Study of the collagen structure in the superficial zone and physiological state of articular cartilage using a 3D confocal imaging technique. Journal of Orthopaedic Surgery and Research, 3(1). doi:10.1186/1749-799X-3-29

  Wu, J. P., Kirk, T. B., & Zheng, M. H

• In vivo confocal laser endomicroscopy of the human liver: a novel method for assessing liver microarchitecture in real time. Endoscopy, 40(7), 554-562. doi:10.1055/s-2008-1077296

  Goetz, M., Kiesslich, R., Dienes, H. P., Drebber, U., Murr, E., Hoffman, A., Kanzler, S., Galle, P. R., Delaney, P., & Neurath, M. F

• Classification of gastric pit patterns by confocal endomicroscopy. Gastrointestinal Endoscopy, 67(6), 843-853. doi:10.1016/j.gie.2008.01.036

  Zhang, J. N., Li, Y. Q., Zhao, Y. A., Yu, T., Zhang, J. P., Guo, Y. T., & Liu, H

• Confocal Laser Endomicroscopy for In Vivo Diagnosis of Early Squamous Cell Carcinoma in the Esophagus. Clinical Gastroenterology and Hepatology, 6(1), 89-94. doi:10.1016/j.cgh.2007.10.013

  Pech, O., Rabenstein, T., Manner, H., Petrone, M. C., Pohl, J., Vieth, M., Stolte, M., & Ell, C

• Current application of confocal endomicroscopy in gastrointestinal disorders. 23(10), 1483-1491. doi:doi:10.1111/j.1440-1746.2008.05469

  Nguyen, N. Q., & Leong, R. W

• Confocal endomicroscopy for in vivo detection of microvascular architecture in normal and malignant lesions of upper gastrointestinal tract. Journal of Gastroenterology and Hepatology (Australia), 23(1), 56-61. doi:10.1111/j.1440-1746.2007.05221

  Liu, H., Li, Y. Q., Yu, T., Zhao, Y. A., Zhang, J. P., Zhang, J. N., Guo, Y. T., Xie, X. J., Zhang, T. G., & Desmond, P. V

• In Vivo Confocal Endomicroscopy in the Diagnosis and Evaluation of Celiac Disease. Gastroenterology, 135(6), 1870-1876. doi:https://doi.org/10.1053/j.gastro.2008.08.054

  Leong, R. W. L., Nguyen, N. Q., Meredith, C. G., Al–Sohaily, S., Kukic, D., Delaney, P. M., Murr, E. R., Yong, J., Merrett, N. D., & Biankin, A. V

• Virtual histology. Best Practice and Research: Clinical Gastroenterology, 22(5), 883-897. doi:10.1016/j.bpg.2008.05.003

  Kiesslich, R., Goetz, M., & Neurath, M. F

• In vivo real-time confocal laser scanning endomicroscopic colonoscopy for the detection and characterization of colorectal neoplasia. British Journal of Surgery, 95(5), 636-645. doi:10.1002/bjs.5988

  Hurlstone, D. P., Baraza, W., Brown, S., Thomson, M., Tiffin, N., & Cross, S. S

• In vivo diagnosis of intestinal spirochaetosis by confocal endomicroscopy. Gut, 57(9), 1331-1333

  Günther, U., Epple, H. J., Heller, F., Leddenkemper, C., Grünbaum, M., Schneider, T., Zeitz, M., & Bojerski, C

• Confocal laser endomicroscopy: In vivo endoscopic tissue analysis. Gastroenterology Nursing, 31(5), 366-369. doi:10.1097/01.SGA.0000338281.86154.60

  Smith, C., Ogilvie, J., & McClelland, L.

• Clinical applicability of in vivo fluorescence confocal microscopy for noninvasive diagnosis and therapeutic monitoring of nonmelanoma skin cancer (Vol. 13): SPIE.

  Astner, S., Dietterle, S., Otberg, N., Röwert-Huber, H.-J., Stockfleth, E., & Lademann, J. M.

2007

• Identification of Epithelial Gaps in Human Small and Large Intestine by Confocal Endomicroscopy. Gastroenterology, 133(6), 1769-1778. doi:https://doi.org/10.1053/j.gastro.2007.09.011

  Kiesslich, R., Goetz, M., Angus, E. M., Hu, Q., Guan, Y., Potten, C., Allen, T., Neurath, M. F., Shroyer, N. F., Montrose, M. H., & Watson, A. J. M

• In vivo subsurface morphological and functional cellular and subcellular imaging of the gastrointestinal tract with confocal mini-microscopy. World Journal of Gastroenterology : WJG, 13(15), 2160-2165. doi:10.3748/wjg.v13.i15.2160

  Goetz, M., Memadathil, B., Biesterfeld, S., Schneider, C., Gregor, S., Galle, P. R., Neurath, M. F., & Kiesslich, R

• Confocal endomicroscopy: A novel imaging technique for in vivo histology of cervical intraepithelial neoplasia. Expert Review of Medical Devices, 4(6), 863-871. doi:10.1586/17434440.4.6.863

  Tan, J., Delaney, P., & McLaren, W. J

• Chromoscopy-guided endomicroscopy increases the diagnostic yield of intraepithelial neoplasia in ulcerative colitis. Gastroenterology, 132(3), 874-882. doi:10.1053/j.gastro.2007.01.048

  Kiesslich, R., Goetz, M., Lammersdorf, K., Schneider, C., Burg, J., Stolte, M., Vieth, M., Nafe, B., Galle, P. R., & Neurath, M. F

• Laser confocal endomicroscopy as a novel technique for fluorescence diagnostic imaging of the oral cavity (Vol. 12): SPIE.

  Thong, P. S.-P., Olivo, M. C., Kho, K.-W., Mancer, K., Zheng, W., Harris, M. R., & Soo, K.-C.

• DEVELOPMENT OF A LASER CONFOCAL ENDOMICROSCOPE FOR IN VIVO FLUORESCENCE IMAGING. Journal of Mechanics in Medicine and Biology, 07(01), 11-18.

  Thong, P. S. P., Kho, K. W., Zheng, W., Harris, M., Soo, K. C., & Olivo, M.

• Application of optical non-invasive methods in skin physiology: a comparison of laser scanning microscopy and optical coherent tomography with histological analysis. 13(2), 119-132. doi:doi:10.1111/j.1600-0846.2007.00208.x

  Lademann, J., Otberg, N., Richter, H., Meyer, L., Audring, H., Teichmann, A., Thomas, S., Knüttel, A., & Sterry, W.

• Stratum corneum architecture of reconstructed human skin models monitored by fluorescent confocal laser scanning microscopy. Laser Physics Letters, 4(4), 308-311. doi:10.1002/lapl.200610107

  Kandárová, H., Richter, H., Liebsch, M., & Lademann, J.

2006

• In Vivo Histology of Barrett’s Esophagus and Associated Neoplasia by Confocal Laser Endomicroscopy. Clinical Gastroenterology and Hepatology, 4(8), 979-987.

  Kiesslich, R., Gossner, L., Goetz, M., Dahlmann, A., Vieth, M., Stolte, M., Hoffman, A., Jung, M., Nafe, B., Galle, P. R., Neurath, M. F. ,

• In vivo fibreoptic confocal imaging (FOCI) of the human ocular surface. Journal of anatomy, 208(2), 197-203. doi:10.1111/j.1469-7580.2006.00521.x

  Wells, A. P., Wakely, L., Birchall, W., & Delaney, P. M.

2005

• Confocal fluorescence endomicroscopic imaging of the tongue, (Vol. 5686): SPIE.

  Zheng, W., Olivo, M., Kho, K. W., Thong, P., Harris, M., & Soo, K. C.

• Fluorescence fibre-optic confocal microscopy of skin in vivo: microscope and fluorophores. 11(4), 254-267. doi:doi:10.1111/j.0909-725X.2005.00152.x

  Suihko, C., Swindle, L. D., Thomas, S. G., & Serup, J.

1999

• Live Confocal Microscopy of Oligonucleotide Uptake by Keratinocytes in Human Skin Grafts on Nude Mice. Journal of Investigative Dermatology, 112(6), 887-892.

  White, P. J., Fogarty, R. D., Liepe, I. J., Werther, G. A., Wraight, C. J., & Delaney, P. M.

1998

• In vivo fibre optic confocal imaging of microvasculature and nerves in the rat vas deferens and colon. 192(4), 489-495. doi:doi:10.1046/j.1469-7580.1998.19240489.x

  PAPWORTH, G. D., DELANEY, P. M., BUSSAU, L. J., VO, L. T., & KING, R. G.

1996

• Assessment of nerve ultrastructure by fibre-optic confocal microscopy. 17(8), 444-448. doi:doi:10.1002/(SICI)1098-2752(1996)17:8<444::AID-MICR5>3.0.CO;2-E

  Cushway, T. R., Lanzetta, M., Cox, G., Trickett, R., & Owen, E. R.