This is a selection of the key Optiscan Imaging publications. For further publication enquiries, please contact support@optiscan.com.

Live fluorescent or antibody labelling

Molecular Imaging of Glucose Metabolism for Intraoperative Fluorescence Guidance During Glioma Surgery. Molecular Imaging and Biology
Belykh, E., Jubran, J. H., George, L. L., Bardonova, L., Healey, D. R., Georges, J. F., . . . Preul, M. C. (2021). 

In vivo intravital endoscopic confocal fluorescence microscopy of normal and acutely injured rat lungs. Laboratory Investigation, 90(6), 824-834
Chagnon, F., Fournier, C., Charette, P. G., Moleski, L., Payet, M. D., Dobbs, L. G., & Lesur, O. (2010). 

Bioinspired Large Stokes Shift Small Molecular Dyes for Biomedical Fluorescence Imaging." Science Advances 8, no. 32 (2022): eabo3289
Chen, Hao, Lingjun Liu, Kun Qian, Hailong Liu, Zhiming Wang, Feng Gao, Chunrong Qu, Wenhao Dai, Daizong Lin, Kaixian Chen, Hong Liu, and Zhen Cheng. 

Assessment of nerve ultrastructure by fibre-optic confocal microscopy. 17(8), 444-448
Cushway, T. R., Lanzetta, M., Cox, G., Trickett, R., & Owen, E. R. (1996). 

In vivo visualization of GL261-luc2 mouse glioma cells by use of Alexa Fluor–labeled TRP-2 antibodies. Neurosurgical Focus, 36(2), E12
Kathryn E. Fenton, Nikolay L. Martirosyan, Mohammed G. Abdelwahab, Stephen W. Coons, Mark C. Preul, & Adrienne C. Scheck. (2014). 

Handheld confocal laser endomicroscopic imaging utilizing tumor-specific fluorescent labeling to identify experimental glioma cells in vivo. Surgical Neurology International, 7(Suppl 40), S995-S1003
Martirosyan, N. L., Georges, J., Kalani, M. Y. S., Nakaji, P., Spetzler, R. F., Feuerstein, B. G., & Preul, M. C. (2016). 

In vivo fibre optic confocal imaging of microvasculature and nerves in the rat vas deferens and colon. 192(4), 489-495
PAPWORTH, G. D., DELANEY, P. M., BUSSAU, L. J., VO, L. T., & KING, R. G. (1998).

November 6th, 2022 by Optiscan
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Intraoperative surgery and tumour margin delineation

Handheld confocal laser endomicroscopic imaging utilizing tumor-specific fluorescent labeling to identify experimental glioma cells in vivo', Surgical Neurology International, 7: S995-S1003
Martirosyan, Nikolay L., Joseph Georges, M. Yashar S. Kalani, Peter Nakaji, Robert F. Spetzler, Burt G. Feuerstein, and Mark C. Preul. 2016. 

In vivo confocal laser laparoscopy allows real time subsurface microscopy in animal models of liver disease', J Hepatol, 48: 91-7
Goetz, M., M. Vieth, S. Kanzler, P. R. Galle, P. Delaney, M. F. Neurath, and R. Kiesslich. 2008. 

Fluorescence-guided resection of tumors in mouse models of oral cancer', Scientific Reports, 10: 11175
Demétrio de Souza França, Paula, Navjot Guru, Sheryl Roberts, Susanne Kossatz, Christian Mason, Marcio Abrahão, Ronald A. Ghossein, Snehal G. Patel, and Thomas Reiner. 2020. 

Validation of the use of a fluorescent PARP1 inhibitor for the detection of oral, oropharyngeal and oesophageal epithelial cancers', Nature Biomedical Engineering, 4: 272-85
Kossatz, Susanne, Giacomo Pirovano, Paula Demétrio De Souza França, Arianna L. Strome, Sumsum P. Sunny, Daniella Karassawa Zanoni, Audrey Mauguen, Brandon Carney, Christian Brand, Veer Shah, Ravindra D. Ramanajinappa, Naveen Hedne, Praveen Birur, Smita Sihag, Ronald A. Ghossein, Mithat Gönen, Marshall Strome, Amritha Suresh, Daniela Molena, Ian Ganly, Moni A. Kuriakose, Snehal G. Patel, and Thomas Reiner. 2020. 

November 5th, 2022 by Optiscan
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Blood vessel, perfusion, and barrier function

Dynamic in vivo Imaging of Microvasculature and Perfusion by Miniaturized Confocal Laser Microscopy', European Surgical Research, 41: 290-97
Goetz, M., S. Thomas, A. Heimann, P. Delaney, C. Schneider, M. Relle, A. Schwarting, P. R. Galle, O. Kempski, M. F. Neurath, and R. Kiesslich. 2008. 

November 4th, 2022 by Optiscan
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Live microflora imaging

In Vivo Histologically Equivalent Evaluation of Gastric Mucosal Topologic Morphology in Dogs By using Confocal Endomicroscopy', Journal of Veterinary Internal Medicine, 28: 799-808
Sharman, M.J., B. Bacci, T. Whittem, and C.S. Mansfield. 2014. 

Comparison of in vivo confocal endomicroscopy with other diagnostic modalities to detect intracellular helicobacters', The Veterinary Journal, 213: 78-83
Sharman, M., B. Bacci, K. Simpson, and C. Mansfield. 2016. 

Confocal laser endomicroscopy is a new imaging modality for recognition of intramucosal bacteria in inflammatory bowel disease in vivo', Gut, 60: 26-33
Moussata, Driffa, Martin Goetz, Annabel Gloeckner, Marcus Kerner, Barry Campbell, Arthur Hoffman, Stephan Biesterfeld, Bernard Flourie, Jean-Christophe Saurin, Peter R. Galle, Markus F. Neurath, Alastair J. M. Watson, and Ralf Kiesslich. 2011. 

November 3rd, 2022 by Optiscan
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Nano particle and drug delivery

Preparation, in vitro and in vivo evaluation of mPEG-PLGA nanoparticles co-loaded with syringopicroside and hydroxytyrosol', Journal of Materials Science: Materials in Medicine, 27: 24
Guan, Qingxia, Shuang Sun, Xiuyan Li, Shaowa Lv, Ting Xu, Jialin Sun, Wenjing Feng, Liang Zhang, and Yongji Li. 2015. 

Bioinspired large Stokes shift small molecular dyes for biomedical fluorescence imaging', Science Advances, 8: eabo3289
Chen, Hao, Lingjun Liu, Kun Qian, Hailong Liu, Zhiming Wang, Feng Gao, Chunrong Qu, Wenhao Dai, Daizong Lin, Kaixian Chen, Hong Liu, and Zhen Cheng. 2022. 

Virus surface-inspired ligand-switchable nanoparticles enable sequential drug delivery for improved oral insulin therapy." In.: Research Square
Yang, Tiantian, Aohua Wang, Di Nie, Weiwei Fan, Xiaohe Jiang, Miaorong Yu, Shiyan Guo, Chunliu Zhu, Gang Wei, and Yong Gan. 2022. 

Fluorescein- and EGFR-Antibody Conjugated Silica Nanoparticles for Enhancement of Real-time Tumor Border Definition Using Confocal Laser Endomicroscopy in Squamous Cell Carcinoma of the Head and Neck', Nanomaterials, 9
Watermann, Anna, Rita Gieringer, Anna-Maria Bauer, Sven Kurch, Ralf Kiesslich, Wolfgang Tremel, Jan Gosepath, and Juergen Brieger. 2019.  

November 2nd, 2022 by Optiscan
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Proof of concept in live models

Identification of Epithelial Gaps in Human Small and Large Intestine by Confocal Endomicroscopy', Gastroenterology, 133: 1769-78.
Kiesslich, Ralf, Martin Goetz, Elizabeth M. Angus, Qiuping Hu, Yanfang Guan, Chris Potten, Terry Allen, Markus F. Neurath, Noah F. Shroyer, Marshall H. Montrose, and Alastair J. M. Watson. 2007. 

In vivo intravital endoscopic confocal fluorescence microscopy of normal and acutely injured rat lungs', Laboratory Investigation, 90: 824-34.
Chagnon, Frederic, Clement Fournier, Paul G. Charette, Luc Moleski, Marcel D. Payet, Leland G. Dobbs, and Olivier Lesur. 2010. 

November 1st, 2022 by Optiscan
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